Population Pharmacokinetics of Liposomal Irinotecan in Patients With Cancer
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چکیده
منابع مشابه
Population Pharmacokinetics of Liposomal Irinotecan in Patients With Cancer
Nanoliposomal irinotecan (nal-IRI) is a liposomal formulation of irinotecan with a longer half-life (t1/2 ), higher plasma total irinotecan (tIRI), and lower SN-38 maximum concentration (Cmax ) compared with nonliposomal irinotecan. Population pharmacokinetic (PK) analysis of nal-IRI was performed for tIRI and total SN-38 (tSN38) using patient samples from six studies. PK-safety association was...
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IHL-305 is a PEGylated liposomal formulation of irinotecan (CPT-11). The objective of this study was to evaluate the factors associated with interpatient variability in the pharmacokinetics and pharmacodynamics of IHL-305 in patients with advanced solid tumors. IHL-305 was administered intravenously once every 4 weeks as part of a Phase I study. Pharmacokinetic studies of the liposomal sum tota...
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ژورنال
عنوان ژورنال: Clinical Pharmacology & Therapeutics
سال: 2017
ISSN: 0009-9236
DOI: 10.1002/cpt.720